In case you have a USB mouse connected to your Mac and it’s not responding, check the Console.app in Applications > Utilities for USB related error entries. If you find the following text in the error log, it might simply be a broken/loose cord and doesn’t mean it’s an OS X software issue:

“The IOUSBFamily is having trouble enumerating a USB device that has been plugged in.

The IOUSBFamily was not able to enumerate a device.”

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